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UniProt functional annotation for G1C794 | ||
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| UniProt code: G1C794. |
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| Organism: | |
Acinetobacter baumannii. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Acinetobacter calcoaceticus/baumannii complex. |
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| Function: | |
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). {ECO:0000256|ARBA:ARBA00002624}. |
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| Catalytic activity: | |
Reaction=Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.; EC=3.4.16.4; Evidence={ECO:0000256|ARBA:ARBA00000871}; |
| Catalytic activity: | |
Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc- (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa- cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma- D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+); Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603, ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033, ChEBI:CHEBI:78435; EC=2.4.1.129; Evidence={ECO:0000256|ARBA:ARBA00023988}; |
| Pathway: | |
Cell wall biogenesis; peptidoglycan biosynthesis. {ECO:0000256|ARBA:ARBA00004752}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000256|ARBA:ARBA00004249}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004249}. Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}. |
| Similarity: | |
In the C-terminal section; belongs to the transpeptidase family. {ECO:0000256|ARBA:ARBA00007090}. |
| Similarity: | |
In the N-terminal section; belongs to the glycosyltransferase 51 family. {ECO:0000256|ARBA:ARBA00007739}. |
Annotations taken from UniProtKB at the EBI.