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UniProt functional annotation for P30403 | ||
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| UniProt code: P30403. |
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| Organism: | |
Calloselasma rhodostoma (Malayan pit viper) (Agkistrodon rhodostoma). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Calloselasma. |
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| Function: | |
[Snake venom metalloproteinase rhodostoxin]: impairs hemostasis in the envenomed animal. {ECO:0000250}. |
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| Function: | |
[Disintegrin rhodostomin]: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors alpha- IIb/beta-3 (ITGA2B/ITGB3). |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; |
| Subunit: | |
Monomeric (disintegrin). {ECO:0000250}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Ptm: | |
Glycans are composed of 4 GlcNAc, 3 Man, 2 Gal, 2 NeuAC and 1 Fuc residue. |
| Similarity: | |
Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.