|
|
||
|
|
|
|
|
UniProt functional annotation for Q8JIV9 | ||
|
|
|
|
|
|
||
| UniProt code: Q8JIV9. |
|
||
| Organism: | |
Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Deinagkistrodon. |
|
||
|
||
| Function: | |
Agglucetin specifically causes platelet aggregation and surface exposure of integrin alpha-IIb/beta-3 with a GPIb-(GP1BA-) dependent manner in washed platelets. It binds to human platelets in a saturable manner, and its binding is specifically blocked by anti-GP Ib mAb. It regulates endothelial cell survival and promotes angiogenesis by activating integrin alpha-v/beta-3 signaling through FAK/phosphatidylinositol 3-kinase (PI3K)/Akt pathway. {ECO:0000269|PubMed:11686327, ECO:0000269|PubMed:18312855}. |
|
||
| Subunit: | |
Heterotetramer of the subunits alpha-1, alpha-2, beta-1 and beta-2; disulfide-linked. {ECO:0000269|PubMed:11686327, ECO:0000269|PubMed:22447656}. |
| Subcellular location: | |
Secreted {ECO:0000250}. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.