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PDBsum entry 3ubd
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Transferase/transferase inhibitor
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PDB id
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3ubd
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Structure of n-terminal domain of rsk2 kinase in complex with flavonoid glycoside sl0101
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Structure:
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Ribosomal protein s6 kinase alpha-3. Chain: a. Fragment: n-terminal kinase domain, unp residues 45-346. Synonym: s6k-alpha-3, 90 kda ribosomal protein s6 kinase 3, p90-rsk 3, p90rsk3, map kinase-activated protein kinase 1b, mapk-activated protein kinase 1b, mapkap kinase 1b, mapkapk-1b, ribosomal s6 kinase 2, rsk-2, pp90rsk2. Engineered: yes
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Source:
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Mus musculus. Mouse. Organism_taxid: 10090. Gene: mapkapk1b, rps6ka-rs1, rps6ka3, rsk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.53Å
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R-factor:
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0.195
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R-free:
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0.223
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Authors:
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D.Utepbergenov,U.Derewenda,Z.S.Derewenda
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Key ref:
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D.Utepbergenov
et al.
(2012).
Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.
Biochemistry,
51,
6499-6510.
PubMed id:
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Date:
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24-Oct-11
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Release date:
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05-Sep-12
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PROCHECK
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Headers
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References
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P18654
(KS6A3_MOUSE) -
Ribosomal protein S6 kinase alpha-3 from Mus musculus
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Seq:
Struc:
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740 a.a.
287 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Biochemistry
51:6499-6510
(2012)
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PubMed id:
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Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.
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D.Utepbergenov,
U.Derewenda,
N.Olekhnovich,
G.Szukalska,
B.Banerjee,
M.K.Hilinski,
D.A.Lannigan,
P.T.Stukenberg,
Z.S.Derewenda.
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ABSTRACT
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Links
