PDBsum entry 3ua7

Transferase/viral protein

PDB id: 3ua7

Contents

Protein chains

63 a.a.

59 a.a.

Ligands

ACE-ALA-PRO-PRO-ILE-PRO-PRO-PRO-ARG

ALA-PRO-PRO-ILE-PRO-PRO-PRO-ARG

GOL

FMT ×2

Metals

_NA

_CL

_ZN ×2

Waters ×173

PDB id:

3ua7

Name:

Transferase/viral protein

Title:

Crystal structure of the human fyn sh3 domain in complex with a peptide from the hepatitis c virus ns5a-protein

Structure:

Tyrosine-protein kinase fyn. Chain: a, b, c, d. Fragment: sh3 domain (unp residues 81-143). Synonym: proto-oncogene syn, proto-oncogenE C-fyn, src-like kinase, slk, p59-fyn. Engineered: yes. Non-structural protein 5a. Chain: e, f. Fragment: proline-rich region (unp residues 350-360).

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Hepatitis c virus. Hcv.

Resolution:

1.50Å R-factor: 0.190 R-free: 0.231

Authors:

J.M.Martin-Garcia,J.Ruiz-Sanz,I.Luque,A.Camara-Artigas

Key ref:

J.M.Martin-Garcia et al. (2012). The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein. Acta Crystallogr D Biol Crystallogr, 68, 1030-1040. PubMed id: 22868769

Date:

21-Oct-11 Release date: 25-Jul-12

Protein chains

P06241  (FYN_HUMAN) -  Tyrosine-protein kinase Fyn from Homo sapiens

Seq: 537 a.a.

Struc: 63 a.a.

Protein chains

P06241  (FYN_HUMAN) -  Tyrosine-protein kinase Fyn from Homo sapiens

Seq: 537 a.a.

Struc: 59 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Acta Crystallogr D Biol Crystallogr 68:1030-1040 (2012)

PubMed id: 22868769

The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein.

J.M.Martin-Garcia, I.Luque, J.Ruiz-Sanz, A.Camara-Artigas.

ABSTRACT

No abstract given.