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PDBsum entry 3ua7

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protein ligands metals Protein-protein interface(s) links
Transferase/viral protein PDB id
3ua7
Jmol PyMol
Contents
Protein chains
63 a.a.
59 a.a.
Ligands
ACE-ALA-PRO-PRO-
ILE-PRO-PRO-PRO-
ARG
ALA-PRO-PRO-ILE-
PRO-PRO-PRO-ARG
GOL
FMT ×2
Metals
_NA
_CL
_ZN ×2
Waters ×173
PDB id:
3ua7
Name: Transferase/viral protein
Title: Crystal structure of the human fyn sh3 domain in complex wit peptide from the hepatitis c virus ns5a-protein
Structure: Tyrosine-protein kinase fyn. Chain: a, b, c, d. Fragment: sh3 domain (unp residues 81-143). Synonym: proto-oncogene syn, proto-oncogenE C-fyn, src-like slk, p59-fyn. Engineered: yes. Non-structural protein 5a. Chain: e, f. Fragment: proline-rich region (unp residues 350-360).
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fyn. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Hepatitis c virus. Hcv.
Resolution:
1.50Å     R-factor:   0.190     R-free:   0.231
Authors: J.M.Martin-Garcia,J.Ruiz-Sanz,I.Luque,A.Camara-Artigas
Key ref: J.M.Martin-Garcia et al. (2012). The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein. Acta Crystallogr D Biol Crystallogr, 68, 1030-1040. PubMed id: 22868769 DOI: 10.1107/S0907444912019798
Date:
21-Oct-11     Release date:   25-Jul-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P06241  (FYN_HUMAN) -  Tyrosine-protein kinase Fyn
Seq:
Struc:
 
Seq:
Struc:
537 a.a.
63 a.a.
Protein chains
Pfam   ArchSchema ?
P06241  (FYN_HUMAN) -  Tyrosine-protein kinase Fyn
Seq:
Struc:
 
Seq:
Struc:
537 a.a.
59 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.2.7.10.2  - Non-specific protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP
+
[protein]-L-tyrosine
Bound ligand (Het Group name = PRO)
matches with 41.18% similarity
= ADP
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
DOI no: 10.1107/S0907444912019798 Acta Crystallogr D Biol Crystallogr 68:1030-1040 (2012)
PubMed id: 22868769  
 
 
The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein.
J.M.Martin-Garcia, I.Luque, J.Ruiz-Sanz, A.Camara-Artigas.
 
  ABSTRACT  
 
No abstract given.

 

 

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