PDBsum entry 3tz7

Transferase/transferase inhibitor

PDB id: 3tz7

Contents

Protein chains

260 a.a.

Ligands

AQB ×2

PDB id:

3tz7

Name:

Transferase/transferase inhibitor

Title:

Kinase domain of csrc in complex with rl103

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a, b. Fragment: kinase domain, unp residues 251-533. Synonym: proto-oncogenE C-src, pp60c-src, p60-src. Engineered: yes. Mutation: yes

Source:

Gallus gallus. Chicken. Organism_taxid: 9031. Gene: src, v-src sarcoma viral oncogene. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

3.30Å R-factor: 0.193 R-free: 0.256

Authors:

C.Gruetter,A.Richters,D.Rauh

Key ref:

A.Richters et al. Overcoming gatekeeper mutations in csrc and abl by hy compound design. To be published, .

Date:

27-Sep-11 Release date: 10-Oct-12

Protein chains

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 260 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site