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PDBsum entry 3twy
Go to PDB code: 
protein ligands metals links
Transferase PDB id
3twy

 

 

 

 

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JSmol PyMol  
Contents
Protein chain
137 a.a.
Ligands
SO4 ×4
Metals
_PB ×2
Waters ×204
PDB id:
3twy
Name: Transferase
Title: Rat pkc c2 domain bound to pb
Structure: Protein kinasE C alpha type. Chain: a. Fragment: unp residues 156-292. Synonym: pkc-a, pkc-alpha. Engineered: yes
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: pkca, prkca. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.50Å     R-factor:   0.204     R-free:   0.219
Authors: P.Li
Key ref: K.A.Morales et al. (2011). Pb2+ as modulator of protein-membrane interactions. J Am Chem Soc, 133, 10599-10611. PubMed id: 21615172
Date:
22-Sep-11     Release date:   02-Nov-11    
Supersedes: 3rdl
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P05696  (KPCA_RAT) -  Protein kinase C alpha type from Rattus norvegicus
Seq:
Struc: 		 
Seq:
Struc: 		672 a.a.
137 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.13  - protein kinase C.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
L-seryl-[protein]
 + ATP
 = O-phospho-L-seryl-[protein]
 + ADP
 + H(+)
L-threonyl-[protein]
 + ATP
 = O-phospho-L-threonyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
J Am Chem Soc 133:10599-10611 (2011)
PubMed id: 21615172  
 
 
Pb2+ as modulator of protein-membrane interactions.
K.A.Morales, M.Lasagna, A.V.Gribenko, Y.Yoon, G.D.Reinhart, J.C.Lee, W.Cho, P.Li, T.I.Igumenova.
 
  ABSTRACT  
 
No abstract given.

 

 

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