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PDBsum entry 3twq
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Signaling protein
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PDB id
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3twq
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PDB id:
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Signaling protein
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Title:
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Crystal structure of arc4 from human tankyrase 2 (apo form)
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Structure:
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Tankyrase-2. Chain: a, b. Fragment: unp residues 484-655. Synonym: tank2, poly [adp-ribose] polymerase 5b, tnks-2, trf1- interacting ankyrin-related adp-ribose polymerase 2, tankyrase ii, tankyrase-like protein, tankyrase-related protein. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: parp5b, tank2, tnkl, tnks2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.15Å
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R-factor:
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0.177
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R-free:
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0.235
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Authors:
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S.Guettler,F.Sicheri
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Key ref:
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S.Guettler
et al.
(2011).
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.
Cell,
147,
1340-1354.
PubMed id:
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Date:
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22-Sep-11
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Release date:
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07-Dec-11
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PROCHECK
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Headers
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References
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Q9H2K2
(TNKS2_HUMAN) -
Poly [ADP-ribose] polymerase tankyrase-2 from Homo sapiens
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Seq:
Struc:
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1166 a.a.
164 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class 2:
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E.C.2.4.2.-
- ?????
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Enzyme class 3:
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E.C.2.4.2.30
- NAD(+) ADP-ribosyltransferase.
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Pathway:
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Reaction:
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NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H+
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NAD(+)
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+
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(ADP-D-ribosyl)n-acceptor
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=
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nicotinamide
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+
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(ADP-D- ribosyl)n+1-acceptor
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Cell
147:1340-1354
(2011)
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PubMed id:
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Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.
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S.Guettler,
J.LaRose,
E.Petsalaki,
G.Gish,
A.Scotter,
T.Pawson,
R.Rottapel,
F.Sicheri.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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B.A.Gibson,
and
W.L.Kraus
(2012).
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs.
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Nat Rev Mol Cell Biol,
13,
411-424.
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J.L.Riffell,
C.J.Lord,
and
A.Ashworth
(2012).
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family.
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Nat Rev Drug Discov,
11,
923-936.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
