 |
PDBsum entry 3tug
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Ligase
|
|
|
Title:
|
|
Crystal structure of the hect domain of itch e3 ubiquitin ligase
|
|
Structure:
|
|
E3 ubiquitin-protein ligase itchy homolog. Chain: a. Synonym: itch, atrophin-1-interacting protein 4, aip4, nfe2- associated polypeptide 1, napp1. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: itch. Expressed in: escherichia coli. Expression_system_taxid: 511693.
|
|
Resolution:
|
|
|
2.27Å
|
R-factor:
|
0.198
|
R-free:
|
0.256
|
|
|
Authors:
|
|
A.Dong,E.Dobrovetsky,S.Xue,C.Butler,A.Wernimont,J.R.Walker,W.Tempel, S.Dhe-Paganon,C.H.Arrowsmith,A.M.Edwards,C.Bountra,Y.Tong,Structural Genomics Consortium (Sgc)
|
|
Key ref:
|
|
E.Dobrovetsky
et al.
Crystal structure of the hect domain of itch e3 ubiqu ligase.
To be published,
.
|
|
|
Date:
|
|
|
16-Sep-11
|
Release date:
|
12-Oct-11
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q96J02
(ITCH_HUMAN) -
E3 ubiquitin-protein ligase Itchy homolog from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
903 a.a.
334 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
|
*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.3.2.26
- HECT-type E3 ubiquitin transferase.
|
|
|
|
|
|
|
Reaction:
|
|
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
|
|
|
|
|
|
|
|
Links
