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UniProt functional annotation for P62328 | ||
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| UniProt codes: P62328, P01253. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250}. |
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| Function: | |
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. {ECO:0000250}. |
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| Subunit: | |
Interacts with SERPINB1 (By similarity). Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. {ECO:0000250, ECO:0000269|PubMed:10848969, ECO:0000269|PubMed:1999398, ECO:0000269|PubMed:23009842}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton. |
| Tissue specificity: | |
Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. {ECO:0000269|PubMed:3500230}. |
| Induction: | |
By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda. {ECO:0000269|PubMed:3500230, ECO:0000269|PubMed:6548414}. |
| Similarity: | |
Belongs to the thymosin beta family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.