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PDBsum entry 3tse

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protein ligands metals links
Hydrolase/hydrolase inhibitor PDB id
3tse
Jmol PyMol
Contents
Protein chain
297 a.a.
Ligands
5EO
Metals
_MG ×3
_ZN
Waters ×163
Superseded by: 4oex
PDB id:
3tse
Name: Hydrolase/hydrolase inhibitor
Title: Crystal structure of the pde5a1 catalytic domain in complex inhibitors
Structure: Cgmp-specific 3',5'-cyclic phosphodiesterase. Chain: a. Fragment: unp residues 535-860. Synonym: cgmp-binding cgmp-specific phosphodiesterase, cgb- engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pde5, pde5a. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.14Å     R-factor:   0.192     R-free:   0.243
Authors: T.T.Chen,T.Chen,Y.C.Xu
Key ref: T.T.Chen et al. Structure of pde5a1 and its inhibitors. To be published, .
Date:
13-Sep-11     Release date:   19-Sep-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
O76074  (PDE5A_HUMAN) -  cGMP-specific 3',5'-cyclic phosphodiesterase
Seq:
Struc:
 
Seq:
Struc:
875 a.a.
297 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.3.1.4.35  - 3',5'-cyclic-GMP phosphodiesterase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate
Guanosine 3',5'-cyclic phosphate
+ H(2)O
= guanosine 5'-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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