PDBsum entry 3tmh

Transport protein/signaling protein

PDB id: 3tmh

Contents

Protein chains

82 a.a.

36 a.a.

39 a.a.

28 a.a.

39 a.a.

33 a.a.

23 a.a.

27 a.a.

Waters ×8

PDB id:

3tmh

Name:

Transport protein/signaling protein

Title:

Crystal structure of dual-specific a-kinase anchoring protein 2 in complex with camp-dependent protein kinase a type ii alpha and pdzk1

Structure:

Na(+)/h(+) exchange regulatory cofactor nhe-rf3. Chain: a, e, i. Fragment: unp residues 375-459. Synonym: nherf-3, cftr-associated protein of 70 kda, na(+)/h(+) exchanger regulatory factor 3, na/pi cotransporter c-terminal- associated protein 1, napi-cap1, pdz domain-containing protein 1, sodium-hydrogen exchanger regulatory factor 3. Engineered: yes. Camp-dependent protein kinase type ii-alpha regulatory

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pdzk1, cap70, nherf3, pdzd1. Expressed in: escherichia coli. Expression_system_taxid: 562. Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116.

Resolution:

3.80Å R-factor: 0.273 R-free: 0.328

Authors:

G.N.Sarma,R.H.Phan,B.Sankaran,S.S.Taylor

Key ref:

G.N.Sarma et al. Differential mode of d-Akap2 to pka isoforms: insight d-Akap2 pka rii pdzk1 ternary complex structure. To be published, .

Date:

31-Aug-11 Release date: 05-Sep-12

Protein chains

Q5T2W1  (NHRF3_HUMAN) -  Na(+)/H(+) exchange regulatory cofactor NHE-RF3 from Homo sapiens

Seq: 519 a.a.

Struc: 82 a.a.

Protein chain

P12368  (KAP2_RAT) -  cAMP-dependent protein kinase type II-alpha regulatory subunit from Rattus norvegicus

Seq: 401 a.a.

Struc: 36 a.a.

Protein chain

P12368  (KAP2_RAT) -  cAMP-dependent protein kinase type II-alpha regulatory subunit from Rattus norvegicus

Seq: 401 a.a.

Struc: 39 a.a.

Protein chain

O43572  (AKA10_HUMAN) -  A-kinase anchor protein 10, mitochondrial from Homo sapiens

Seq: 662 a.a.

Struc: 28 a.a.*

Protein chain

P12368  (KAP2_RAT) -  cAMP-dependent protein kinase type II-alpha regulatory subunit from Rattus norvegicus

Seq: 401 a.a.

Struc: 39 a.a.

Protein chain

P12368  (KAP2_RAT) -  cAMP-dependent protein kinase type II-alpha regulatory subunit from Rattus norvegicus

Seq: 401 a.a.

Struc: 33 a.a.

Protein chain

O43572  (AKA10_HUMAN) -  A-kinase anchor protein 10, mitochondrial from Homo sapiens

Seq: 662 a.a.

Struc: 23 a.a.*

Protein chain

O43572  (AKA10_HUMAN) -  A-kinase anchor protein 10, mitochondrial from Homo sapiens

Seq: 662 a.a.

Struc: 27 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)