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PDBsum entry 3tlp

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protein metals Protein-protein interface(s) links
Transcription PDB id
3tlp

 

 

 

 

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Contents
Protein chains
119 a.a.
Metals
_NI ×4
Waters ×78
PDB id:
3tlp
Name: Transcription
Title: Crystal structure of the fourth bromodomain of human poly-bromodomain containing protein 1 (pb1)
Structure: Protein polybromo-1. Chain: a, b. Fragment: unp residues 496-637. Synonym: hpb1, brg1-associated factor 180, baf180, polybromo-1d. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: baf180, pb1, pbrm1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.13Å     R-factor:   0.204     R-free:   0.249
Authors: P.Filippakopoulos,I.Felletar,S.Picaud,T.Keates,J.Muniz,T.Krojer, C.K.Allerston,S.Latwiel,F.Von Delft,C.H.Arrowsmith,A.M.Edwards, J.Weigelt,C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
Key ref: P.Filippakopoulos et al. (2012). Histone recognition and large-scale structural analysis of the human bromodomain family. Cell, 149, 214-231. PubMed id: 22464331
Date:
30-Aug-11     Release date:   28-Sep-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q86U86  (PB1_HUMAN) -  Protein polybromo-1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1689 a.a.
119 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Cell 149:214-231 (2012)
PubMed id: 22464331  
 
 
Histone recognition and large-scale structural analysis of the human bromodomain family.
P.Filippakopoulos, S.Picaud, M.Mangos, T.Keates, J.P.Lambert, D.Barsyte-Lovejoy, I.Felletar, R.Volkmer, S.Müller, T.Pawson, A.C.Gingras, C.H.Arrowsmith, S.Knapp.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23211769 C.A.Musselman, M.E.Lalonde, J.Côté, and T.G.Kutateladze (2012).
Perceiving the epigenetic landscape through histone readers.
  Nat Struct Mol Biol, 19, 1218-1227.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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