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PDBsum entry 3tjv
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PDB id:
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Hydrolase
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Title:
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Crystal structure of human granzyme h with a peptidyl substrate
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Structure:
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Granzyme h. Chain: a. Synonym: gzmh, ccp-x, cathepsin g-like 2, ctsgl2, cytotoxic t- lymphocyte proteinase, cytotoxic serine proteasE C, csp-c. Engineered: yes. Mutation: yes. Ptsyagddsg. Chain: b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: gzmh, cgl2, ctsgl2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence is a synthetic construct.
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Resolution:
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2.40Å
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R-factor:
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0.234
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R-free:
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0.243
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Authors:
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L.Wang,K.Zhang,L.Wu,L.Tong,F.Sun,Z.Fan
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Key ref:
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L.Wang
et al.
(2012).
Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif.
J Immunol,
188,
765-773.
PubMed id:
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Date:
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25-Aug-11
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Release date:
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28-Dec-11
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PROCHECK
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Headers
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References
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P20718
(GRAH_HUMAN) -
Granzyme H from Homo sapiens
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Seq:
Struc:
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246 a.a.
225 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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J Immunol
188:765-773
(2012)
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PubMed id:
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Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif.
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L.Wang,
K.Zhang,
L.Wu,
S.Liu,
H.Zhang,
Q.Zhou,
L.Tong,
F.Sun,
Z.Fan.
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ABSTRACT
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Links
