UniProt functional annotation for P16086



	UniProt functional annotation for P16086

UniProt code: P16086.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. {ECO:0000250}.

Subunit: Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats). Interacts with CLN3; this interaction regulates the fodrin localization at the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q13813, ECO:0000269|PubMed:11971983, ECO:0000269|PubMed:15994232, ECO:0000269|PubMed:23897824}.

Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15994232}. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.

Tissue specificity: Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). {ECO:0000269|PubMed:15994232}.

Developmental stage: Expressed throughout glomerulogenesis. {ECO:0000269|PubMed:15994232}.

Ptm: Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. {ECO:0000269|PubMed:11971983}.

Similarity: Belongs to the spectrin family. {ECO:0000305}.

Sequence caution: Sequence=AAA40770.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. {ECO:0000250}.


Subunit:		Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats). Interacts with CLN3; this interaction regulates the fodrin localization at the plasma membrane (By similarity). {ECO:0000250\|UniProtKB:Q13813, ECO:0000269\|PubMed:11971983, ECO:0000269\|PubMed:15994232, ECO:0000269\|PubMed:23897824}.
Subcellular location:		Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269\|PubMed:15994232}. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Tissue specificity:		Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level). {ECO:0000269\|PubMed:15994232}.
Developmental stage:		Expressed throughout glomerulogenesis. {ECO:0000269\|PubMed:15994232}.
Ptm:		Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro. {ECO:0000269\|PubMed:11971983}.
Similarity:		Belongs to the spectrin family. {ECO:0000305}.
Sequence caution:		Sequence=AAA40770.1; Type=Frameshift; Evidence={ECO:0000305};