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UniProt functional annotation for P13726 | ||
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| UniProt code: P13726. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269|PubMed:12652293}. |
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| Subunit: | |
Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. {ECO:0000269|PubMed:20634491, ECO:0000269|PubMed:8598903, ECO:0000269|PubMed:9925787}. |
| Subcellular location: | |
[Isoform 1]: Membrane {ECO:0000269|PubMed:12652293}; Single-pass type I membrane protein {ECO:0000269|PubMed:12652293}. |
| Subcellular location: | |
[Isoform 2]: Secreted {ECO:0000269|PubMed:12652293}. |
| Tissue specificity: | |
Lung, placenta and pancreas. {ECO:0000269|PubMed:12652293}. |
| Induction: | |
TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF- alpha, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response. {ECO:0000269|PubMed:19168442}. |
| Similarity: | |
Belongs to the tissue factor family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.