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PDBsum entry 3tgx
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protein ligands metals Protein-protein interface(s) links
Cytokine/cytokine receptor PDB id
3tgx

 

 

 

 

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Contents
Protein chains
(+ 2 more) 208 a.a.
115 a.a.
117 a.a.
107 a.a.
Ligands
NAG-NAG-BMA-MAN-
MAN-MAN-FUL ×5
NAG-NAG-BMA-MAN-
MAN-FUL ×2
NAG-NAG-BMA-MAN-
MAN-FUC
MAN ×8
SO4 ×39
Metals
_NI ×4
PDB id:
3tgx
Name: Cytokine/cytokine receptor
Title: Il-21:il21r complex
Structure: Interleukin-21 receptor. Chain: a, c, e, g, i, k, m, o. Fragment: interleukin 21 receptor extracellular domain. Synonym: il-21 receptor, il-21r, novel interleukin receptor. Engineered: yes. Mutation: yes. Interleukin-21. Chain: b, d, f, h, j, l, n, p. Fragment: unp residues 23-155.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: il21r, nilr, unq3121/pro10273. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: il21. Expressed in: escherichia coli.
Resolution:
2.80Å     R-factor:   0.244     R-free:   0.273
Authors: O.J.Hamming,L.Kang,A.Svenson,J.L.Karlsen,H.Rahbek-Nielsen, S.R.Paludan,S.A.Hjort,K.Bondensgaard,R.Hartmann
Key ref: O.J.Hamming et al. (2012). Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R. J Biol Chem, 287, 9454-9460. PubMed id: 22235133
Date:
18-Aug-11     Release date:   15-Feb-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9HBE5  (IL21R_HUMAN) -  Interleukin-21 receptor from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		538 a.a.
208 a.a.*
Protein chains
Pfam   ArchSchema ?
Q9HBE4  (IL21_HUMAN) -  Interleukin-21 from Homo sapiens
Seq:
Struc: 		162 a.a.
115 a.a.
Protein chains
Pfam   ArchSchema ?
Q9HBE4  (IL21_HUMAN) -  Interleukin-21 from Homo sapiens
Seq:
Struc: 		162 a.a.
117 a.a.
Protein chains
Pfam   ArchSchema ?
Q9HBE4  (IL21_HUMAN) -  Interleukin-21 from Homo sapiens
Seq:
Struc: 		162 a.a.
107 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 

 
J Biol Chem 287:9454-9460 (2012)
PubMed id: 22235133  
 
 
Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R.
O.J.Hamming, L.Kang, A.Svensson, J.L.Karlsen, H.Rahbek-Nielsen, S.R.Paludan, S.A.Hjorth, K.Bondensgaard, R.Hartmann.
 
  ABSTRACT  
 
No abstract given.

 

 

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