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Ligand clusters for UniProt code P28482

Ligand clusters for P28482: Mitogen-activated protein kinase 1 OS=Homo sapiens GN=MAPK1 PE=1 SV=3

Top 6 (of 37) ligand clusters
Cluster 1.
32 ligand types
48 ligands
Cluster 2.
3 ligand types
8 ligands
Cluster 3.
3 ligand types
4 ligands
Cluster 4.
3 ligand types
9 ligands
Cluster 5.
3 ligand types
8 ligands
Cluster 6.
2 ligand types
4 ligands
Representative protein: 3sa0A  
 

Structures

PDB   Schematic diagram
3sa0A    
4fv4A    
4fv9A    
4n0sA    
3w55A    
 more ...

 

 Cluster 1 contains 32 ligand types (of which only 20 are listed. Click for all)

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Ligand Description


 
1. Ligand: F29 × 1
1-Allyl-5-(2-Phenylpyrazolo[1,5-A]pyridin-3-Yl)-1h- Pyrazolo[3,4-C]pyridazin-3-Amine
PDB code: 1wzy(A).


 
2. Ligand: 82A × 1
(S)-N-(1-(3-Chloro-4-Fluorophenyl)-2-Hydroxyethyl)-4- (4-(3-Chlorophenyl)-1h-Pyrazol-3-Yl)-1h-
Pyrrole-2- Carboxamide
PDB code: 2ojj(A).


 
3. Ligand: 19A × 1
N,N-Dimethyl-4-(4-Phenyl-1h-Pyrazol-3-Yl)-1h-Pyrrole- 2-Carboxamide
PDB code: 2ojg(A).


 
4. Ligand: 33A × 1
N-Benzyl-4-[4-(3-Chlorophenyl)-1h-Pyrazol-3-Yl]-1h- Pyrrole-2-Carboxamide
PDB code: 2oji(A).


 
5. Ligand: FRZ × 1
5-(2-Phenylpyrazolo[1,5-A]pyridin-3-Yl)-1h-Pyrazolo[3, 4-C]pyridazin-3-Amine
PDB code: 1tvo(A).


 
6. Ligand: SB2 × 1
4-[5-(4-Fluoro-Phenyl)-2-(4-Methanesulfinyl-Phenyl)- 3h-Imidazol-4-Yl]-Pyridine
PDB code: 1pme(A).


 
7. Ligand: EDO × 10
1,2-Ethanediol
PDB codes: 4fuy(A), 4fv0(A), 4fv1(A), 4fv2(A), 4fv3(A), 4fv7(A), 4g6o(A), 4qta(A), 4qte(A),


 
8. Ligand: ANP × 6
Phosphoaminophosphonic acid-Adenylate ester
PDB codes: 2y9q(A), 3tei(A), 4fmq(A), 4h3p(A), 4h3q(A), 4nif(B).


 
9. Ligand: SO4 × 3
Sulfate ion
PDB codes: 4fux(A), 4g6n(A), 4iz5(A).


 
10. Ligand: 1FM × 1
(3s,5z,8s,9s,11e)-8,9,16-Trihydroxy-14-Methoxy-3- Methyl-3,4,9,10-Tetrahydro-1h-2-
Benzoxacyclotetradecine-1,7(8h)-Dione
PDB code: 3w55(A).


 
11. Ligand: 2SH × 1
N-[(1s)-1-(3-Chloro-4-Fluorophenyl)-2-Hydroxyethyl]-2- (Tetrahydro-2h-Pyran-4-Ylamino)-5,8-
Dihydropyrido[3,4- D]pyrimidine-7(6h)-Carboxamide
PDB code: 4o6e(A).


 
12. Ligand: 38Z × 1
(3r)-1-(2-Oxo-2-{4-[4-(Pyrimidin-2-Yl)phenyl]piperazin- 1-Yl}ethyl)-N-[3-(Pyridin-4-Yl)-2h-Indazol-
5- Yl]pyrrolidine-3-Carboxamide
PDB code: 4qta(A).


 
13. Ligand: 390 × 1
4-{2-[(2-Chloro-4-Fluorophenyl)amino]-5- Methylpyrimidin-4-Yl}-N-[(1s)-1-(3-Chlorophenyl)-2-
Hydroxyethyl]-1h-Pyrrole-2-Carboxamide
PDB code: 4qte(A).


 
14. Ligand: ADP × 1
Adenosine-5'-Diphosphate
PDB code: 4iz5(A).


 
15. Ligand: DHC × 1
Caffeic acid
PDB code: 4n0s(A).


 
16. Ligand: E28 × 1
4-{4-[4-(Aminomethyl)-3-(Trifluoromethyl)phenyl]-1h- Pyrazol-5-Yl}-N-(2,3-Dihydro-1-Benzofuran-5-
Ylmethyl)- 1h-Pyrrole-2-Carboxamide
PDB code: 4g6o(A).


 
17. Ligand: E57 × 1
N-[(1s)-1-(3-Chlorophenyl)-2-Hydroxyethyl]-4-(2-{[(2s)- 1-Hydroxybutan-2-Yl]amino}-5-
Methylpyrimidin-4-Yl)-1h- Pyrrole-2-Carboxamide
PDB code: 4fv6(A).


 
18. Ligand: E63 × 1
6-({4-[(3-Cyclopropyl-1h-Pyrazol-5-Yl)amino]-5- (Phenylamino)pyrimidin-2-Yl}amino)-1,2-Dihydro-3h-
Indazol-3-One
PDB code: 4fv8(A).


 
19. Ligand: E71 × 1
3-[4-(2,3-Difluorophenyl)-1,2-Oxazol-5-Yl]-5-(Pyridin- 4-Yl)-1h-Pyrrolo[2,3-B]pyridine
PDB code: 4fv9(A).


 
20. Ligand: E75 × 1
Trans-4-{[4-(5-Methyl-3-Phenyl-1,2-Oxazol-4-Yl) pyrimidin-2-Yl]amino}cyclohexanol
PDB code: 4fux(A).

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 Cluster 2 contains 3 ligand types

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Ligand Description


 
1. Ligand: EDO × 6
1,2-Ethanediol
PDB codes: 4fv0(A), 4fv3(A), 4fv7(A), 4g6o(A), 4qte(A),


 
2. Ligand: GOL × 1
Glycerol
PDB code: 4fv2(A).


 
3. Ligand: PEG × 1
Di(hydroxyethyl)ether
PDB code: 4n0s(A).

 

 Cluster 3 contains 3 ligand types

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Ligand Description


 
1. Ligand: EDO × 2
1,2-Ethanediol
PDB codes: 4fv0(A), 4fv2(A).


 
2. Ligand: GOL × 1
Glycerol
PDB code: 4fv7(A).


 
3. Ligand: SO4 × 1
Sulfate ion
PDB code: 4qte(A).

 

 Cluster 4 contains 3 ligand types

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Ligand Description


 
1. Ligand: EDO × 6
1,2-Ethanediol
PDB codes: 4fv5(A), 4fv6(A), 4fv7(A), 4fv8(A), 4fv9(A), 4qte(A).


 
2. Ligand: SO4 × 2
Sulfate ion
PDB codes: 4nif(B), 4qta(A).


 
3. Ligand: GOL × 1
Glycerol
PDB code: 4fv4(A).

 

 Cluster 5 contains 3 ligand types

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Ligand Description


 
1. Ligand: SO4 × 5
Sulfate ion
PDB codes: 3i5z(A), 4fv5(A), 4fv8(A), 4fv9(A), 4iz5(A).


 
2. Ligand: EDO × 2
1,2-Ethanediol
PDB codes: 4fv1(A), 4qte(A).

_Na
 
3. Metal: _NA × 1
PDB code: 4nif(B).

 

 Cluster 6 contains 2 ligand types

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Ligand Description


 
1. Ligand: GOL × 3
Glycerol
PDB codes: 4fv0(A), 4fv1(A), 4fv2(A).


 
2. Ligand: EDO × 1
1,2-Ethanediol
PDB code: 4qte(A).

 

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