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PDBsum entry 3tdd

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protein ligands Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3tdd
Jmol PyMol
Contents
Protein chains
250 a.a.
244 a.a.
241 a.a.
242 a.a.
233 a.a.
244 a.a.
243 a.a.
222 a.a.
204 a.a.
198 a.a.
212 a.a.
222 a.a.
233 a.a.
196 a.a.
Ligands
BFO ×2
Waters ×1339
PDB id:
3tdd
Name: Hydrolase/hydrolase inhibitor
Title: Crystal structure of yeast cp in complex with belactosin c
Structure: Proteasome component y7. Chain: a, o. Synonym: macropain subunit y7, multicatalytic endopeptidase subunit y7, proteinase ysce subunit 7. Proteasome component y13. Chain: b, p. Synonym: macropain subunit y13, multicatalytic endopeptidas subunit y13, proteinase ysce subunit 13. Proteasome component pre6.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Resolution:
2.70Å     R-factor:   0.212     R-free:   0.236
Authors: V.S.Korotkov,A.Ludwig,O.V.Larionov,A.V.Lygin,M.Groll,A.De Me
Key ref: V.S.Korotkov et al. (2011). Synthesis and biological activity of optimized belactosin C congeners. Org Biomol Chem, 9, 7791-7798. PubMed id: 21946808 DOI: 10.1039/c1ob05661a
Date:
10-Aug-11     Release date:   12-Oct-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P23639  (PSA2_YEAST) -  Proteasome subunit alpha type-2
Seq:
Struc:
250 a.a.
250 a.a.
Protein chains
Pfam   ArchSchema ?
P23638  (PSA4_YEAST) -  Proteasome subunit alpha type-3
Seq:
Struc:
258 a.a.
244 a.a.
Protein chains
Pfam   ArchSchema ?
P40303  (PSA7_YEAST) -  Proteasome subunit alpha type-4
Seq:
Struc:
254 a.a.
241 a.a.
Protein chains
Pfam   ArchSchema ?
P32379  (PSA5_YEAST) -  Proteasome subunit alpha type-5
Seq:
Struc:
260 a.a.
242 a.a.
Protein chains
Pfam   ArchSchema ?
P40302  (PSA1_YEAST) -  Proteasome subunit alpha type-6
Seq:
Struc:
234 a.a.
233 a.a.
Protein chains
Pfam   ArchSchema ?
P21242  (PSA3_YEAST) -  Probable proteasome subunit alpha type-7
Seq:
Struc:
288 a.a.
244 a.a.
Protein chains
Pfam   ArchSchema ?
P21243  (PSA6_YEAST) -  Proteasome subunit alpha type-1
Seq:
Struc:
252 a.a.
243 a.a.
Protein chains
Pfam   ArchSchema ?
P25043  (PSB7_YEAST) -  Proteasome subunit beta type-2
Seq:
Struc:
261 a.a.
222 a.a.
Protein chains
Pfam   ArchSchema ?
P25451  (PSB3_YEAST) -  Proteasome subunit beta type-3
Seq:
Struc:
205 a.a.
204 a.a.
Protein chains
Pfam   ArchSchema ?
P22141  (PSB2_YEAST) -  Proteasome subunit beta type-4
Seq:
Struc:
198 a.a.
198 a.a.
Protein chains
Pfam   ArchSchema ?
P30656  (PSB5_YEAST) -  Proteasome subunit beta type-5
Seq:
Struc:
287 a.a.
212 a.a.
Protein chains
Pfam   ArchSchema ?
P23724  (PSB1_YEAST) -  Proteasome subunit beta type-6
Seq:
Struc:
241 a.a.
222 a.a.
Protein chains
Pfam   ArchSchema ?
P30657  (PSB4_YEAST) -  Proteasome subunit beta type-7
Seq:
Struc:
266 a.a.
233 a.a.
Protein chains
Pfam   ArchSchema ?
P38624  (PSB6_YEAST) -  Proteasome subunit beta type-1
Seq:
Struc:
215 a.a.
196 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z: E.C.3.4.25.1  - Proteasome endopeptidase complex.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Cleavage at peptide bonds with very broad specificity.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     plasma membrane   14 terms 
  Biological process     response to salt stress   10 terms 
  Biochemical function     molecular_function     7 terms  

 

 
DOI no: 10.1039/c1ob05661a Org Biomol Chem 9:7791-7798 (2011)
PubMed id: 21946808  
 
 
Synthesis and biological activity of optimized belactosin C congeners.
V.S.Korotkov, A.Ludwig, O.V.Larionov, A.V.Lygin, M.Groll, A.de Meijere.
 
  ABSTRACT  
 
No abstract given.

 

 

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