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PDB id:
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Immune system
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Title:
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Crystal structure of HIV-1 neutralizing antibody ch04
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Structure:
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Ch04 heavy chain fab. Chain: h, a. Engineered: yes. Ch04 light chain fab. Chain: l, b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293f. Expression_system_cell_line: hek293f
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Resolution:
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1.91Å
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R-factor:
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0.198
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R-free:
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0.238
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Authors:
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R.K.Louder,J.S.Mclellan,M.Pancera,Y.Yang,B.Zhang,M.Bonsignori, P.D.Kwong
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Key ref:
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J.S.McLellan
et al.
(2011).
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
Nature,
480,
336-343.
PubMed id:
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Date:
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09-Aug-11
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Release date:
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30-Nov-11
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PROCHECK
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Headers
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References
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Nature
480:336-343
(2011)
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PubMed id:
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Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
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J.S.McLellan,
M.Pancera,
C.Carrico,
J.Gorman,
J.P.Julien,
R.Khayat,
R.Louder,
R.Pejchal,
M.Sastry,
K.Dai,
S.O'Dell,
N.Patel,
S.Shahzad-ul-Hussan,
Y.Yang,
B.Zhang,
T.Zhou,
J.Zhu,
J.C.Boyington,
G.Y.Chuang,
D.Diwanji,
I.Georgiev,
Y.D.Kwon,
D.Lee,
M.K.Louder,
S.Moquin,
S.D.Schmidt,
Z.Y.Yang,
M.Bonsignori,
J.A.Crump,
S.H.Kapiga,
N.E.Sam,
B.F.Haynes,
D.R.Burton,
W.C.Koff,
L.M.Walker,
S.Phogat,
R.Wyatt,
J.Orwenyo,
L.X.Wang,
J.Arthos,
C.A.Bewley,
J.R.Mascola,
G.J.Nabel,
W.R.Schief,
A.B.Ward,
I.A.Wilson,
P.D.Kwong.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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D.C.Ekiert,
A.K.Kashyap,
J.Steel,
A.Rubrum,
G.Bhabha,
R.Khayat,
J.H.Lee,
M.A.Dillon,
R.E.O'Neil,
A.M.Faynboym,
M.Horowitz,
L.Horowitz,
A.B.Ward,
P.Palese,
R.Webby,
R.A.Lerner,
R.R.Bhatt,
and
I.A.Wilson
(2012).
Cross-neutralization of influenza A viruses mediated by a single antibody loop.
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Nature,
489,
526-532.
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PDB codes:
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F.Klein,
A.Halper-Stromberg,
J.A.Horwitz,
H.Gruell,
J.F.Scheid,
S.Bournazos,
H.Mouquet,
L.A.Spatz,
R.Diskin,
A.Abadir,
T.Zang,
M.Dorner,
E.Billerbeck,
R.N.Labitt,
C.Gaebler,
P.M.Marcovecchio,
R.B.Incesu,
T.R.Eisenreich,
P.D.Bieniasz,
M.S.Seaman,
P.J.Bjorkman,
J.V.Ravetch,
A.Ploss,
and
M.C.Nussenzweig
(2012).
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
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Nature,
492,
118-122.
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M.Rolland,
P.T.Edlefsen,
B.B.Larsen,
S.Tovanabutra,
E.Sanders-Buell,
T.Hertz,
A.C.deCamp,
C.Carrico,
S.Menis,
C.A.Magaret,
H.Ahmed,
M.Juraska,
L.Chen,
P.Konopa,
S.Nariya,
J.N.Stoddard,
K.Wong,
H.Zhao,
W.Deng,
B.S.Maust,
M.Bose,
S.Howell,
A.Bates,
M.Lazzaro,
A.O'Sullivan,
E.Lei,
A.Bradfield,
G.Ibitamuno,
V.Assawadarachai,
R.J.O'Connell,
M.S.deSouza,
S.Nitayaphan,
S.Rerks-Ngarm,
M.L.Robb,
J.S.McLellan,
I.Georgiev,
P.D.Kwong,
J.M.Carlson,
N.L.Michael,
W.R.Schief,
P.B.Gilbert,
J.I.Mullins,
and
J.H.Kim
(2012).
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2.
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Nature,
490,
417-420.
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P.C.Wilson,
and
S.F.Andrews
(2012).
Tools to therapeutically harness the human antibody response.
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Nat Rev Immunol,
12,
709-719.
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P.R.Dormitzer,
G.Grandi,
and
R.Rappuoli
(2012).
Structural vaccinology starts to deliver.
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Nat Rev Microbiol,
10,
807-813.
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Y.Mao,
L.Wang,
C.Gu,
A.Herschhorn,
S.H.Xiang,
H.Haim,
X.Yang,
and
J.Sodroski
(2012).
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer.
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Nat Struct Mol Biol,
19,
893-899.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
