PDBsum entry 3t9v

Transport protein

PDB id: 3t9v

Contents

Protein chains

258 a.a.

Ligands

CNI ×2

Metals

_ZN ×4

Waters ×535

PDB id:

3t9v

Name:

Transport protein

Title:

Cnqx bound to a reduced double cysteine mutant (a452c/s652c) of the ligand binding domain of glua2

Structure:

Glutamate receptor 2. Chain: a, b. Fragment: see remark 999. Synonym: glua2, glur2, ampa-selective glutamate receptor 2, glur-b, glur-k2. Engineered: yes. Mutation: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: gria2,glua2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.98Å R-factor: 0.181 R-free: 0.238

Authors:

A.H.Ahmed,R.E.Oswald

Key ref:

A.H.Ahmed et al. (2011). Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations. J Biol Chem, 286, 35257-35266. PubMed id: 21846932

Date:

03-Aug-11 Release date: 17-Aug-11

Protein chains

P19491  (GRIA2_RAT) -  Glutamate receptor 2 from Rattus norvegicus

Seq: 883 a.a.

Struc: 258 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

J Biol Chem 286:35257-35266 (2011)

PubMed id: 21846932

Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations.

A.H.Ahmed, S.Wang, H.H.Chuang, R.E.Oswald.

ABSTRACT

No abstract given.