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UniProt functional annotation for Q7Z3T8 | ||
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| UniProt code: Q7Z3T8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. {ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}. |
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| Subunit: | |
Interacts with the C-terminus of TOM1. Does not interact with TOM1L1 or TOM1L2. {ECO:0000269|PubMed:14613930, ECO:0000269|Ref.15}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:11546807}. Early endosome membrane {ECO:0000269|PubMed:11546807}; Peripheral membrane protein {ECO:0000269|PubMed:11546807}. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P). |
| Tissue specificity: | |
Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes. {ECO:0000269|PubMed:11546807}. |
| Domain: | |
The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P. {ECO:0000269|PubMed:11546807}. |
| Sequence caution: | |
Sequence=BAA20764.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.