 |
PDBsum entry 3t3m
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Cell adhesion
|
PDB id
|
|
|
|
3t3m
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
454 a.a.
|
|
|
|
|
|
|
|
|
|
|
466 a.a.
|
|
|
|
|
|
|
|
|
|
|
214 a.a.
|
|
|
|
|
|
|
|
|
|
|
214 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Cell adhesion
|
|
|
Title:
|
|
A novel high affinity integrin alphaiibbeta3 receptor antagonist that unexpectedly displaces mg2+ from the beta3 midas
|
|
Structure:
|
|
Integrin alpha-iib. Chain: a, c. Fragment: unp residues 32-488. Synonym: gpalpha iib, gpiib, platelet membrane glycoprotein iib, integrin alpha-iib heavy chain, integrin alpha-iib light chain, form 1, integrin alpha-iib light chain, form 2. Engineered: yes. Integrin beta-3. Chain: b, d.
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: itga2b, gp2b, itgab. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: itgb3, gp3a. Mus musculus. Organism_taxid: 10090.
|
|
Resolution:
|
|
|
2.60Å
|
R-factor:
|
0.180
|
R-free:
|
0.222
|
|
|
Authors:
|
|
J.Zhu,J.Zhu,T.A.Springer
|
|
Key ref:
|
|
J.Zhu
et al.
(2012).
Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.
Sci Transl Med,
4,
125ra32-125ra32.
PubMed id:
|
|
|
Date:
|
|
|
25-Jul-11
|
Release date:
|
28-Mar-12
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P08514
(ITA2B_HUMAN) -
Integrin alpha-IIb from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1039 a.a.
454 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
P05106
(ITB3_HUMAN) -
Integrin beta-3 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
788 a.a.
466 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Sci Transl Med
4:125ra32-125ra32
(2012)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.
|
|
J.Zhu,
W.S.Choi,
J.G.McCoy,
A.Negri,
J.Zhu,
S.Naini,
J.Li,
M.Shen,
W.Huang,
D.Bougie,
M.Rasmussen,
R.Aster,
C.J.Thomas,
M.Filizola,
T.A.Springer,
B.S.Coller.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
| | |
Links
