PDBsum entry 3sz7

Chaperone regulator

PDB id

3sz7

Loading ...

Contents

			Protein chain

					151 a.a.

			Waters ×109

PDB id:

3sz7

Links

Name:

Chaperone regulator

Title:

Crystal structure of the sgt2 tpr domain from aspergillus fumigatus

Structure:

Hsc70 cochaperone (sgt). Chain: a. Fragment: unp residues 109-267. Engineered: yes

Source:

Aspergillus fumigatus. Organism_taxid: 330879. Strain: atcc mya-4609 / af293 / cbs 101355 / fgsc a1100. Gene: afua_1g09830. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.72Å

R-factor:

0.173

R-free:

0.208

Authors:

J.W.Chartron,G.M.Gonzalez,W.M.Clemons Jr.

Key ref:

J.W.Chartron et al. (2011). A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex. J Biol Chem, 286, 34325-34334. PubMed id: 21832041

Date:

18-Jul-11

Release date:

10-Aug-11

PROCHECK

	Headers

	References

Protein chain

Q4WTC0 (Q4WTC0_ASPFU) - Heat-shock protein cognate (HSC) co-chaperone sgt12 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)

Seq: Struc:					341 a.a. 151 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 4 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.3.1.3.16 - protein-serine/threonine phosphatase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

1.	O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
2.	O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate

O-phospho-L-seryl-[protein]	+	H2O	=	L-seryl-[protein]	+	phosphate

O-phospho-L-threonyl-[protein]	+	H2O	=	L-threonyl-[protein]	+	phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	J Biol Chem 286:34325-34334 (2011)
PubMed id: 21832041

A structural model of the Sgt2 protein and its interactions with chaperones and the Get4/Get5 complex.
J.W.Chartron, G.M.Gonzalez, W.M.Clemons.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22086371

R.S.Hegde, and R.J.Keenan (2011).
Tail-anchored membrane protein insertion into the endoplasmic reticulum.

Nat Rev Mol Cell Biol, 12, 787-798.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.