PDBsum entry 3sxr

Transferase/transferase inhibitor

PDB id: 3sxr

Contents

Protein chains

260 a.a.

Ligands

1N1 ×2

SO4 ×3

Waters ×212

PDB id:

3sxr

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of bmx non-receptor tyrosine kinase complex with dasatinib

Structure:

Cytoplasmic tyrosine-protein kinase bmx. Chain: a, b. Fragment: unp residues 411-675. Synonym: bone marrow tyrosine kinase gene in chromosome x protein, epithelial and endothelial tyrosine kinase, etk, ntk38. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: agmx1, atk, bmx, bpk, btk. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Resolution:

2.40Å R-factor: 0.189 R-free: 0.231

Authors:

J.Sack,J.Muckelbauer

Key ref:

J.Muckelbauer et al. (2011). X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase. Chem Biol Drug Des, 78, 739-748. PubMed id: 21883956

Date:

15-Jul-11 Release date: 21-Sep-11

Protein chains

P51813  (BMX_HUMAN) -  Cytoplasmic tyrosine-protein kinase BMX from Homo sapiens

Seq: 675 a.a.

Struc: 260 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Chem Biol Drug Des 78:739-748 (2011)

PubMed id: 21883956

X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase.

J.Muckelbauer, J.S.Sack, N.Ahmed, J.Burke, C.Y.Chang, M.Gao, J.Tino, D.Xie, A.J.Tebben.

ABSTRACT

No abstract given.