PDBsum entry 3spk

Hydorlase/hydorlase inhibitor

PDB id: 3spk

Contents

Protein chains

99 a.a.

Ligands

TPV ×2

Waters ×351

PDB id:

3spk

Name:

Hydorlase/hydorlase inhibitor

Title:

Tipranavir in complex with a human immunodeficiency virus type 1 protease variant

Structure:

HIV-1 protease. Chain: a, b. Fragment: HIV-1 protease. Engineered: yes. Mutation: yes

Source:

Human immunodeficiency virus type 1. HIV. Organism_taxid: 11676. Gene: pol. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.24Å R-factor: 0.177 R-free: 0.227

Authors:

Y.Wang,Z.Liu,J.S.Brunzelle,I.A.Kovari,L.C.Kovari

Key ref:

Y.Wang et al. (2011). The higher barrier of darunavir and tipranavir resistance for HIV-1 protease. Biochem Biophys Res Commun, 412, 737-742. PubMed id: 21871444

Date:

01-Jul-11 Release date: 12-Oct-11

Protein chains

Q000H7  (Q000H7_9HIV1) -  Pol protein (Fragment) from Human immunodeficiency virus 1

Seq: 404 a.a.

Struc: 99 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.26.13 - retroviral ribonuclease H.

Biochem Biophys Res Commun 412:737-742 (2011)

PubMed id: 21871444

The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.

Y.Wang, Z.Liu, J.S.Brunzelle, I.A.Kovari, T.G.Dewdney, S.J.Reiter, L.C.Kovari.

ABSTRACT

No abstract given.