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PDBsum entry 3sow
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PDB id:
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Ligase
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Title:
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Structure of uhrf1 phd finger in complex with histone h3k4me3 1-9 peptide
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Structure:
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E3 ubiquitin-protein ligase uhrf1. Chain: a, b. Fragment: uhrf1 (unp residues 298-367). Synonym: inverted ccaat box-binding protein of 90 kda, nuclear protein 95, nuclear zinc finger protein np95, hunp95, ring finger protein 106, transcription factor icbp90, ubiquitin-like phd and ring finger domain-containing protein 1, ubiquitin-like-containing phd and ring finger domains protein 1. Engineered: yes.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: icbp90, np95, rnf106, uhrf1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: chemically synthesized
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Resolution:
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1.95Å
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R-factor:
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0.205
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R-free:
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0.247
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Authors:
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E.Rajakumara,D.J.Patel
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Key ref:
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E.Rajakumara
et al.
(2011).
PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.
Mol Cell,
43,
275-284.
PubMed id:
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Date:
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30-Jun-11
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Release date:
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03-Aug-11
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PROCHECK
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Headers
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References
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Q96T88
(UHRF1_HUMAN) -
E3 ubiquitin-protein ligase UHRF1 from Homo sapiens
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Seq:
Struc:
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793 a.a.
67 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.3.2.27
- RING-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Mol Cell
43:275-284
(2011)
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PubMed id:
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PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.
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E.Rajakumara,
Z.Wang,
H.Ma,
L.Hu,
H.Chen,
Y.Lin,
R.Guo,
F.Wu,
H.Li,
F.Lan,
Y.G.Shi,
Y.Xu,
D.J.Patel,
Y.Shi.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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C.A.Musselman,
M.E.Lalonde,
J.Côté,
and
T.G.Kutateladze
(2012).
Perceiving the epigenetic landscape through histone readers.
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Nat Struct Mol Biol,
19,
1218-1227.
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E.L.Greer,
and
Y.Shi
(2012).
Histone methylation: a dynamic mark in health, disease and inheritance.
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Nat Rev Genet,
13,
343-357.
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S.B.Rothbart,
K.Krajewski,
N.Nady,
W.Tempel,
S.Xue,
A.I.Badeaux,
D.Barsyte-Lovejoy,
J.Y.Martinez,
M.T.Bedford,
S.M.Fuchs,
C.H.Arrowsmith,
and
B.D.Strahl
(2012).
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation.
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Nat Struct Mol Biol,
19,
1155-1160.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
