PDBsum entry 3sla

Signaling protein

PDB id: 3sla

Contents

Protein chains

166 a.a.

156 a.a.

Ligands

GOL ×8

Metals

_NA ×2

Waters ×86

PDB id:

3sla

Name:

Signaling protein

Title:

X-ray structure of first four repeats of human beta-catenin

Structure:

Catenin beta-1. Chain: a, b, c, d, e. Synonym: beta-catenin. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: beta catenin, ctnnb, ctnnb1, ok/sw-cl.35, pro2286. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.50Å R-factor: 0.221 R-free: 0.277

Authors:

D.Gupta,M.Bienz

Key ref:

M.de la Roche et al. (2012). An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nat Commun, 3, 680-680. PubMed id: 22353711

Date:

24-Jun-11 Release date: 29-Feb-12

Protein chains

P35222  (CTNB1_HUMAN) -  Catenin beta-1 from Homo sapiens

Seq: 781 a.a.

Struc: 166 a.a.

Protein chains

P35222  (CTNB1_HUMAN) -  Catenin beta-1 from Homo sapiens

Seq: 781 a.a.

Struc: 156 a.a.

Nat Commun 3:680-680 (2012)

PubMed id: 22353711

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.

M.de la Roche, T.J.Rutherford, D.Gupta, D.B.Veprintsev, B.Saxty, S.M.Freund, M.Bienz.

ABSTRACT

No abstract given.