PDBsum entry 3sl9

Signaling protein, protein binding

PDB id: 3sl9

Contents

Protein chains

164 a.a.

27 a.a.

23 a.a.

27 a.a.

20 a.a.

Ligands

EDO ×11

PEG ×5

IMD ×7

GOL ×5

Waters ×152

PDB id:

3sl9

Name:

Signaling protein, protein binding

Title:

X-ray structure of beta catenin in complex with bcl9

Structure:

Catenin beta-1. Chain: a, b, e, g. Synonym: beta-catenin. Engineered: yes. B-cell cll/lymphoma 9 protein. Chain: c, d, f, h. Synonym: b-cell lymphoma 9 protein, bcl-9, protein legless homolog. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: beta catenin, ctnnb, ctnnb1, ok/sw-cl.35, pro2286. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: bcl9.

Resolution:

2.20Å R-factor: 0.197 R-free: 0.249

Authors:

D.Gupta,M.Bienz

Key ref:

M.de la Roche et al. (2012). An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nat Commun, 3, 680-680. PubMed id: 22353711

Date:

24-Jun-11 Release date: 29-Feb-12

Protein chains

P35222  (CTNB1_HUMAN) -  Catenin beta-1 from Homo sapiens

Seq: 781 a.a.

Struc: 164 a.a.

Protein chain

O00512  (BCL9_HUMAN) -  B-cell CLL/lymphoma 9 protein from Homo sapiens

Seq: 1426 a.a.

Struc: 27 a.a.

Protein chain

O00512  (BCL9_HUMAN) -  B-cell CLL/lymphoma 9 protein from Homo sapiens

Seq: 1426 a.a.

Struc: 23 a.a.

Protein chain

O00512  (BCL9_HUMAN) -  B-cell CLL/lymphoma 9 protein from Homo sapiens

Seq: 1426 a.a.

Struc: 27 a.a.

Protein chain

O00512  (BCL9_HUMAN) -  B-cell CLL/lymphoma 9 protein from Homo sapiens

Seq: 1426 a.a.

Struc: 20 a.a.

Nat Commun 3:680-680 (2012)

PubMed id: 22353711

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.

M.de la Roche, T.J.Rutherford, D.Gupta, D.B.Veprintsev, B.Saxty, S.M.Freund, M.Bienz.

ABSTRACT

No abstract given.