PDBsum entry 3sl8

Hydrolase/hydrolase inhibitor

PDB id: 3sl8

Contents

Protein chains

327 a.a.

Ligands

EDO ×30

PEG ×2

JN7 ×4

PO4 ×2

DMS ×2

Metals

_ZN ×8

Waters ×236

PDB id:

3sl8

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of the catalytic domain of pde4d2 with compound 10o

Structure:

Camp-specific 3',5'-cyclic phosphodiesterase 4d. Chain: a, b, c, d. Fragment: catalytic domain, unp residues 381-741. Synonym: dpde3, pde43. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pde4d, dpde3. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.60Å R-factor: 0.200 R-free: 0.273

Authors:

S.F.Feil

Key ref:

J.L.Nankervis et al. (2011). Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2. Bioorg Med Chem Lett, 21, 7089-7093. PubMed id: 22030030

Date:

24-Jun-11 Release date: 26-Oct-11

Protein chains

Q08499  (PDE4D_HUMAN) -  3',5'-cyclic-AMP phosphodiesterase 4D from Homo sapiens

Seq: 809 a.a.

Struc: 327 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.4.53 - 3',5'-cyclic-AMP phosphodiesterase.
• Reaction: 3',5'-cyclic AMP + H2O = AMP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Bioorg Med Chem Lett 21:7089-7093 (2011)

PubMed id: 22030030

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

J.L.Nankervis, S.C.Feil, N.C.Hancock, Z.Zheng, H.L.Ng, C.J.Morton, J.K.Holien, P.W.Ho, M.M.Frazzetto, I.G.Jennings, D.T.Manallack, T.J.Martin, P.E.Thompson, M.W.Parker.

ABSTRACT

No abstract given.