PDBsum entry 3sjv

Immune system

PDB id: 3sjv

Contents

Protein chains

277 a.a.

99 a.a.

197 a.a.

241 a.a.

Ligands

PHE-LEU-ARG-GLY-ARG-ALA-TYR-GLY-LEU ×4

PDB id:

3sjv

Name:

Immune system

Title:

Crystal structure of the rl42 tcr in complex with hla-b8-flr

Structure:

Hla class i histocompatibility antigen, b-8 alpha chain. Chain: a, f, k, p. Fragment: extracellular domain residues 25-301. Synonym: mhc class i antigen b 8. Engineered: yes. Beta-2-microglobulin. Chain: b, g, l, q. Synonym: beta-2-microglobulin form pi 5.3. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-b, hlab. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes. Human herpesvirus 4.

Resolution:

3.10Å R-factor: 0.256 R-free: 0.321

Authors:

S.Gras,P.G.Wilmann,C.Zhenjun,H.Hanim,L.Yu Chih,L.Kjer-Nielsen, A.W.Purcell,S.R.Burrows,J.Mccluskey,J.Rossjohn

Key ref:

S.Gras et al. (2012). A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule. J Immunol, 188, 311-321. PubMed id: 22140258

Date:

22-Jun-11 Release date: 29-Feb-12

Protein chains

P01889  (1B07_HUMAN) -  HLA class I histocompatibility antigen, B alpha chain from Homo sapiens

Seq: 362 a.a.

Struc: 277 a.a.*

Protein chains

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 99 a.a.

Protein chains

P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens

Seq: 140 a.a.

Struc: 197 a.a.*

Protein chains

No UniProt id for this chain

Struc: 241 a.a.

* PDB and UniProt seqs differ at 13 residue positions (black crosses)

J Immunol 188:311-321 (2012)

PubMed id: 22140258

A structural basis for varied αβ TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule.

S.Gras, P.G.Wilmann, Z.Chen, H.Halim, Y.C.Liu, L.Kjer-Nielsen, A.W.Purcell, S.R.Burrows, J.McCluskey, J.Rossjohn.

ABSTRACT

No abstract given.