PDBsum entry 3shf

Apoptosis

PDB id: 3shf

Contents

Protein chain

1133 a.a.

Ligands

ADP

GBL ×2

Waters ×73

PDB id:

3shf

Name:

Apoptosis

Title:

Crystal structure of the r265s mutant of full-length murine apaf-1

Structure:

Apoptotic peptidase activating factor 1. Chain: a. Synonym: apaf-1. Engineered: yes. Mutation: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Cell_line: sf21. Gene: apaf1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21

Resolution:

3.55Å R-factor: 0.230 R-free: 0.305

Authors:

S.Eschenburg,T.F.Reubold

Key ref:

T.F.Reubold et al. (2011). Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure, 19, 1074-1083. PubMed id: 21827944

Date:

16-Jun-11 Release date: 24-Aug-11

Protein chain

O88879  (APAF_MOUSE) -  Apoptotic protease-activating factor 1 from Mus musculus

Seq: 1249 a.a.

Struc: 1133 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Structure 19:1074-1083 (2011)

PubMed id: 21827944

Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.

T.F.Reubold, S.Wohlgemuth, S.Eschenburg.

ABSTRACT

No abstract given.