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PDBsum entry 3sgk
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Immune system PDB id
3sgk

 

 

 

 

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Contents
Protein chains
209 a.a.
165 a.a.
Ligands
NAG-NAG-BMA-MAN-
NAG-MAN-NAG-NAG ×2
NAG-NAG-BMA-MAN-
MAN-MAN-MAN-MAN
NAG-NAG
MLI
Waters ×135
PDB id:
3sgk
Name: Immune system
Title: Unique carbohydrate/carbohydrate interactions are required for high affinity binding of fcgiii and antibodies lacking core fucose
Structure: Fc fragment. Chain: a, b. Fragment: unp residues 106-330. Engineered: yes. Human fcg3a receptor. Chain: c. Fragment: unp residues 19-208. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ighg1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: fcgr3a, cd16a, fcg3, fcgr3, igfr3. Expressed in: homo sapiens. Expression_system_taxid: 9606.
Resolution:
2.40Å     R-factor:   0.207     R-free:   0.250
Authors: C.Ferrara,S.Grau,C.Jaeger,P.Sondermann,P.Bruenker,I.Waldhauer, M.Hennig,A.Ruf,A.C.Rufer,M.Stihle,P.Umana,J.Benz
Key ref: C.Ferrara et al. (2011). Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Proc Natl Acad Sci U S A, 108, 12669-12674. PubMed id: 21768335
Date:
15-Jun-11     Release date:   03-Aug-11    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P01857  (IGHG1_HUMAN) -  Immunoglobulin heavy constant gamma 1 from Homo sapiens
Seq:
Struc: 		399 a.a.
209 a.a.
Protein chain
Pfam   ArchSchema ?
P08637  (FCG3A_HUMAN) -  Low affinity immunoglobulin gamma Fc region receptor III-A from Homo sapiens
Seq:
Struc: 		254 a.a.
165 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 4 residue positions (black crosses)

 

 
Proc Natl Acad Sci U S A 108:12669-12674 (2011)
PubMed id: 21768335  
 
 
Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.
C.Ferrara, S.Grau, C.Jäger, P.Sondermann, P.Brünker, I.Waldhauer, M.Hennig, A.Ruf, A.C.Rufer, M.Stihle, P.Umaña, J.Benz.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
23411799 I.Schwab, and F.Nimmerjahn (2013).
Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
  Nat Rev Immunol, 13, 176-189.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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