PDBsum entry 3sfj

Signaling protein/inhibitor

PDB id: 3sfj

Contents

Protein chains

103 a.a.

Ligands

ALA-ASN-SER-ARG-TRP-PRO-THR-SER-ILE-ILE ×2

Waters ×256

PDB id:

3sfj

Name:

Signaling protein/inhibitor

Title:

Crystal structure of tax-interacting protein-1 (tip-1) pdz domain bound to ical36 inhibitor peptide

Structure:

Tax1-binding protein 3. Chain: a, c. Fragment: pdz domain (unp residues 10-112). Synonym: tax-interacting protein-1, tip-1, glutaminase-interacting protein 3. Engineered: yes. Decameric peptide ical36. Chain: b, d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tax1bp3, tip1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes

Resolution:

1.24Å R-factor: 0.181 R-free: 0.193

Authors:

J.F.Amacher,D.R.Madden

Key ref:

P.R.Cushing et al. A cal inhibitor with single-Pdz specificity rescues deltaf508-Cftr. To be published, .

Date:

13-Jun-11 Release date: 12-Dec-12

Protein chains

O14907  (TX1B3_HUMAN) -  Tax1-binding protein 3 from Homo sapiens

Seq: 124 a.a.

Struc: 103 a.a.

Enzyme reactions

• Enzyme class: E.C.?