PDBsum entry 3s9c

Hydrolase

PDB id

3s9c

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Contents

			Protein chain

					234 a.a.

			Ligands

					ILE-ALA-ALA-TRP- TYR-LEU-ARG


					NAG-NAG-BMA


					BGC


					GLC


					ACT ×4

			Metals

					_ZN ×3

			Waters ×196

PDB id:

3s9c

Links

Name:

Hydrolase

Title:

Russell's viper venom serine proteinase, rvv-v in complex with the fragment (residues 1533-1546) of human factor v

Structure:

Vipera russelli proteinase rvv-v gamma. Chain: a. Synonym: factor v-activating proteinase gamma, snake venom factor v activator gamma. Coagulation factor v. Chain: b. Fragment: unp residues 1561-1574. Synonym: activated protein c cofactor, proaccelerin, labile factor. Engineered: yes

Source:

Daboia russellii siamensis. Siamese russell's viper. Organism_taxid: 343250. Tissue: venom. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Other_details: synthetic peptide

Resolution:

1.80Å

R-factor:

0.183

R-free:

0.218

Authors:

D.Nakayama,Y.Ben Ammar,S.Takeda

Key ref:

D.Nakayama et al. (2011). Structural basis of coagulation factor V recognition for cleavage by RVV-V. Febs Lett, 585, 3020-3025. PubMed id: 21871889

Date:

01-Jun-11

Release date:

07-Sep-11

PROCHECK

	Headers

	References

Protein chain

P18965 (VSPG_DABSI) - Factor V activator RVV-V gamma from Daboia siamensis

Seq: Struc:					260 a.a. 234 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.3.4.21.95 - snake venom factor V activator.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Fully activates pure human clotting factor V by a single cleavage at the Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly bond. Bovine, but not rabbit factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO(2).

	Febs Lett 585:3020-3025 (2011)
PubMed id: 21871889

Structural basis of coagulation factor V recognition for cleavage by RVV-V.
D.Nakayama, Y.Ben Ammar, T.Miyata, S.Takeda.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22948927

S.S.Cha, Y.J.An, C.S.Jeong, M.K.Kim, S.G.Lee, K.H.Lee, and B.H.Oh (2012).
Experimental phasing using zinc anomalous scattering.

Acta Crystallogr D Biol Crystallogr, 68, 1253-1258.

PDB codes:

4dt3 4dwz 4fc5

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.