PDBsum entry 3s98

Signaling protein receptor

PDB id

3s98

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Contents

			Protein chain

					270 a.a.

			Ligands

					NAG

			Waters ×145

PDB id:

3s98

Links

Name:

Signaling protein receptor

Title:

Human ifnar1

Structure:

Interferon alpha/beta receptor 1. Chain: a. Fragment: unp residues 30-332. Synonym: ifn-r-1, ifn-alpha/beta receptor 1, cytokine receptor class- ii member 1, cytokine receptor family 2 member 1, crf2-1, type i interferon receptor 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ifnar1, ifnar. Expressed in: trichoplusia ni. Expression_system_taxid: 7111

Resolution:

1.90Å

R-factor:

0.210

R-free:

0.234

Authors:

C.Thomas,K.C.Garcia

Key ref:

C.Thomas et al. (2011). Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell, 146, 621-632. PubMed id: 21854986

Date:

01-Jun-11

Release date:

31-Aug-11

PROCHECK

	Headers

	References

Protein chain

P17181 (INAR1_HUMAN) - Interferon alpha/beta receptor 1 from Homo sapiens

Seq: Struc:

Seq: Struc:					557 a.a. 270 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	Cell 146:621-632 (2011)
PubMed id: 21854986

Structural linkage between ligand discrimination and receptor activation by type I interferons.
C.Thomas, I.Moraga, D.Levin, P.O.Krutzik, Y.Podoplelova, A.Trejo, C.Lee, G.Yarden, S.E.Vleck, J.S.Glenn, G.P.Nolan, J.Piehler, G.Schreiber, K.C.Garcia.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22426547

C.Thomas, J.F.Bazan, and K.C.Garcia (2012).
Structure of the activating IL-1 receptor signaling complex.

Nat Struct Mol Biol, 19, 455-457.

PDB code:

4dep

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