PDBsum entry 3s4s

Immune system

PDB id: 3s4s

Contents

Protein chains

178 a.a.

186 a.a.

13 a.a.

176 a.a.

Ligands

GOL ×3

Waters ×68

PDB id:

3s4s

Name:

Immune system

Title:

Crystal structure of cd4 mutant bound to hla-dr1

Structure:

Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, d. Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, e. Fragment: unp residues 30-221. Synonym: mhc class ii antigen drb1 1, Dr-1, dr1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: hla-drb1. Gene: cd4. Expressed in: spodoptera frugiperda.

Resolution:

2.40Å R-factor: 0.251 R-free: 0.286

Authors:

Y.Li

Key ref:

X.X.Wang et al. (2011). Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc Natl Acad Sci U S A, 108, 15960-15965. PubMed id: 21900604

Date:

20-May-11 Release date: 21-Sep-11

Protein chains

P01903  (DRA_HUMAN) -  HLA class II histocompatibility antigen, DR alpha chain from Homo sapiens

Seq: 254 a.a.

Struc: 178 a.a.*

Protein chains

P01911  (2B1F_HUMAN) -  HLA class II histocompatibility antigen, DRB1 beta chain from Homo sapiens

Seq: 266 a.a.

Struc: 186 a.a.*

Protein chains

P03437  (HEMA_I68A0) -  Hemagglutinin from Influenza A virus (strain A/Aichi/2/1968 H3N2)

Seq: 566 a.a.

Struc: 13 a.a.

Protein chains

P01730  (CD4_HUMAN) -  T-cell surface glycoprotein CD4 from Homo sapiens

Seq: 458 a.a.

Struc: 176 a.a.*

* PDB and UniProt seqs differ at 17 residue positions (black crosses)

Proc Natl Acad Sci U S A 108:15960-15965 (2011)

PubMed id: 21900604

Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.

X.X.Wang, Y.Li, Y.Yin, M.Mo, Q.Wang, W.Gao, L.Wang, R.A.Mariuzza.

ABSTRACT

No abstract given.