PDBsum entry 3s36

Immune system/transferase

PDB id: 3s36

Contents

Protein chains

214 a.a.

214 a.a.

112 a.a.

PDB id:

3s36

Name:

Immune system/transferase

Title:

Structural basis for the function of two anti-vegf receptor antibodies

Structure:

1121b light chain. Chain: l. Engineered: yes. 1121b heavy chain. Chain: h. Engineered: yes. Vascular endothelial growth factor receptor 2. Chain: x. Fragment: domain 3 of vegf receptor 2, unp residues 220-338.

Source:

Mus musculus, homo sapiens. Mouse, human. Organism_taxid: 10090, 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: mammalian kidney cells hek293. Homo sapiens. Human. Organism_taxid: 9606.

Resolution:

3.20Å R-factor: 0.277 R-free: 0.332

Authors:

M.C.Franklin

Key ref:

M.C.Franklin et al. (2011). The structural basis for the function of two anti-VEGF receptor 2 antibodies. Structure, 19, 1097-1107. PubMed id: 21827946

Date:

17-May-11 Release date: 24-Aug-11

Protein chain

No UniProt id for this chain

Struc: 214 a.a.

Protein chain

No UniProt id for this chain

Struc: 214 a.a.

Protein chain

P35968  (VGFR2_HUMAN) -  Vascular endothelial growth factor receptor 2 from Homo sapiens

Seq: 1356 a.a.

Struc: 112 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chain X: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Structure 19:1097-1107 (2011)

PubMed id: 21827946

The structural basis for the function of two anti-VEGF receptor 2 antibodies.

M.C.Franklin, E.C.Navarro, Y.Wang, S.Patel, P.Singh, Y.Zhang, K.Persaud, A.Bari, H.Griffith, L.Shen, P.Balderes, P.Kussie.

ABSTRACT

No abstract given.