PDBsum entry 3rxh

Hydrolase/hydrolase inhibitor

PDB id: 3rxh

Contents

Protein chain

223 a.a.

Ligands

GOL ×3

DMS ×2

HSM

Metals

_CA

Waters ×313

PDB id:

3rxh

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of trypsin complexed with 2-(1h-imidazol-4-yl) ethanamine

Structure:

Cationic trypsin. Chain: a. Synonym: beta-trypsin, alpha-trypsin chain 1, alpha-trypsin chain 2. Ec: 3.4.21.4

Source:

Bos taurus. Bovine. Organism_taxid: 9913

Resolution:

1.70Å R-factor: 0.164 R-free: 0.184

Authors:

J.Yamane,M.Yao,Y.Zhou,I.Tanaka

Key ref:

J.Yamane et al. (2011). In-Crystal affinity ranking of fragment hit compounds reveals a relationship with their inhibitory activiti. J appl crystallogr, 44, 798.

Date:

10-May-11 Release date: 24-Aug-11

Protein chain

P00760  (TRY1_BOVIN) -  Serine protease 1 from Bos taurus

Seq: 246 a.a.

Struc: 223 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.21.4 - trypsin.
• Reaction: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.