UniProt functional annotation for Q3HNM7



	UniProt functional annotation for Q3HNM7

UniProt code: Q3HNM7.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis (PubMed:16301171, PubMed:21816348). May regulate cell proliferation and differentiation in the developing nervous system (PubMed:16301171). May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (PubMed:16094321). {ECO:0000269|PubMed:16094321, ECO:0000269|PubMed:16301171, ECO:0000269|PubMed:21816348}.

Subunit: Interacts with ALS2CR19/PAR3B and GPSM1/AGS3 (By similarity). Interacts with F2RL2/PAR3 (PubMed:16094321). Interacts with GPSM2/LGN (via TPR repeat region) (PubMed:16094321, PubMed:21816348). {ECO:0000250|UniProtKB:Q1MX18, ECO:0000269|PubMed:16094321, ECO:0000269|PubMed:21816348}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:16094321, ECO:0000269|PubMed:16301171, ECO:0000269|PubMed:21816348}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q1MX18}. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. {ECO:0000250|UniProtKB:Q1MX18}.

Tissue specificity: Expressed in brain, kidney, liver, testis and skin. {ECO:0000269|PubMed:16094321, ECO:0000269|PubMed:16301171}.

Developmental stage: Expressed at 12.5 dpc in dorsal root and cranial glanglia in the developing brain. Detected at 14.5 dpc in skin epidermis (at protein level). First detected at 10.5 dpc in the dorsal root glanglia and cranial glanglia. At 12.5 dpc expression appears in retina, forebrain and outside of the nervous system. At 13.5 dpc a strong expression is detected in the cortex. Expressed in embryonic, newborn and adult skin. {ECO:0000269|PubMed:16094321}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis (PubMed:16301171, PubMed:21816348). May regulate cell proliferation and differentiation in the developing nervous system (PubMed:16301171). May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (PubMed:16094321). {ECO:0000269\|PubMed:16094321, ECO:0000269\|PubMed:16301171, ECO:0000269\|PubMed:21816348}.


Subunit:		Interacts with ALS2CR19/PAR3B and GPSM1/AGS3 (By similarity). Interacts with F2RL2/PAR3 (PubMed:16094321). Interacts with GPSM2/LGN (via TPR repeat region) (PubMed:16094321, PubMed:21816348). {ECO:0000250\|UniProtKB:Q1MX18, ECO:0000269\|PubMed:16094321, ECO:0000269\|PubMed:21816348}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:16094321, ECO:0000269\|PubMed:16301171, ECO:0000269\|PubMed:21816348}. Cytoplasm, cell cortex {ECO:0000250\|UniProtKB:Q1MX18}. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. {ECO:0000250\|UniProtKB:Q1MX18}.
Tissue specificity:		Expressed in brain, kidney, liver, testis and skin. {ECO:0000269\|PubMed:16094321, ECO:0000269\|PubMed:16301171}.
Developmental stage:		Expressed at 12.5 dpc in dorsal root and cranial glanglia in the developing brain. Detected at 14.5 dpc in skin epidermis (at protein level). First detected at 10.5 dpc in the dorsal root glanglia and cranial glanglia. At 12.5 dpc expression appears in retina, forebrain and outside of the nervous system. At 13.5 dpc a strong expression is detected in the cortex. Expressed in embryonic, newborn and adult skin. {ECO:0000269\|PubMed:16094321}.