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PDBsum entry 3rn8
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Transport protein
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PDB id
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3rn8
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PDB id:
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| Name: |
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Transport protein
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Title:
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Crystal structure of iglur2 ligand binding domain and symmetrical carboxyl containing potentiator
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Structure:
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Glutamate receptor 2. Chain: a, b, c. Fragment: unp residues 413-527, 653-812. Synonym: glur-2, ampa-selective glutamate receptor 2, glur-b, glur- k2, glutamate receptor ionotropic, ampa 2, glua2. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: gria2, glur2. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.70Å
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R-factor:
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0.191
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R-free:
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0.224
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Authors:
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D.E.Timm
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Key ref:
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D.E.Timm
et al.
(2011).
Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Mol Pharmacol,
80,
267-280.
PubMed id:
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Date:
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22-Apr-11
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Release date:
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25-May-11
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PROCHECK
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Headers
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References
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P42262
(GRIA2_HUMAN) -
Glutamate receptor 2 from Homo sapiens
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Seq:
Struc:
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883 a.a.
258 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Mol Pharmacol
80:267-280
(2011)
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PubMed id:
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Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
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D.E.Timm,
M.Benveniste,
A.M.Weeks,
E.S.Nisenbaum,
K.M.Partin.
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ABSTRACT
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Links
