UniProt functional annotation for M4B6G6



	UniProt functional annotation for M4B6G6

UniProt code: M4B6G6.

Organism: Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent) (Peronospora arabidopsidis).

Taxonomy: Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae; Hyaloperonospora.

Function: Secreted effector that acts as an elicitor of hypersensitive response (HR) specifically on plants carrying both defense protein RPP1 from several ecotypes including RPP1-NdA, RPP1-WsB, RPP1-EstA and RPP1- ZdrA. {ECO:0000269|PubMed:15894715, ECO:0000269|PubMed:22194907, ECO:0000269|PubMed:25671309, ECO:0000269|PubMed:26725254, ECO:0000269|PubMed:27427964, ECO:0000269|PubMed:29794019}.

Subunit: Monomer (PubMed:21788488). Interacts with defense protein RPP1 from several ecotypes including RPP1-NdA, RPP1-WsB, RPP1-EstA and RPP1- ZdrA, via their leucine-rich repeats (LLRs) (PubMed:25671309, PubMed:26725254). {ECO:0000269|PubMed:21788488, ECO:0000269|PubMed:25671309, ECO:0000269|PubMed:26725254}.

Subcellular location: Secreted {ECO:0000269|PubMed:15894715}. Host cytoplasm {ECO:0000269|PubMed:15894715}.

Domain: The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3- phosphate (PIP). However ATR1 does not bind to PIPs, even though it harbors the RxLR-dEER motif at the N-terminus, suggesting that the RxLR-dEER motif is insufficient for PIP binding. {ECO:0000269|PubMed:19047742, ECO:0000269|PubMed:23425855, ECO:0000305|PubMed:15894715}.

Domain: The tandem repeated WY domains are involved in the recognition of the RPP1 defense proteins of the different Arabidopsis thaliana ecotypes. {ECO:0000269|PubMed:21788488, ECO:0000269|PubMed:26725254}.

Miscellaneous: The ATR1 effector protein of Hyaloperonospora arabidopsidis is a polymorphic member of the RXLR class of secreted effectors. The ATR1 alleles are differentially recognized by RPP1 genes from different Arabidopsis ecotypes (Niederzenz, Wassilewskija, Estland and Zdarec). {ECO:0000269|PubMed:15894715, ECO:0000269|PubMed:22194907, ECO:0000269|PubMed:25671309, ECO:0000269|PubMed:26725254}.

Similarity: Belongs to the RxLR effector family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent) (Peronospora arabidopsidis).
Taxonomy:		Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae; Hyaloperonospora.



Function:		Secreted effector that acts as an elicitor of hypersensitive response (HR) specifically on plants carrying both defense protein RPP1 from several ecotypes including RPP1-NdA, RPP1-WsB, RPP1-EstA and RPP1- ZdrA. {ECO:0000269\|PubMed:15894715, ECO:0000269\|PubMed:22194907, ECO:0000269\|PubMed:25671309, ECO:0000269\|PubMed:26725254, ECO:0000269\|PubMed:27427964, ECO:0000269\|PubMed:29794019}.


Subunit:		Monomer (PubMed:21788488). Interacts with defense protein RPP1 from several ecotypes including RPP1-NdA, RPP1-WsB, RPP1-EstA and RPP1- ZdrA, via their leucine-rich repeats (LLRs) (PubMed:25671309, PubMed:26725254). {ECO:0000269\|PubMed:21788488, ECO:0000269\|PubMed:25671309, ECO:0000269\|PubMed:26725254}.
Subcellular location:		Secreted {ECO:0000269\|PubMed:15894715}. Host cytoplasm {ECO:0000269\|PubMed:15894715}.
Domain:		The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3- phosphate (PIP). However ATR1 does not bind to PIPs, even though it harbors the RxLR-dEER motif at the N-terminus, suggesting that the RxLR-dEER motif is insufficient for PIP binding. {ECO:0000269\|PubMed:19047742, ECO:0000269\|PubMed:23425855, ECO:0000305\|PubMed:15894715}.
Domain:		The tandem repeated WY domains are involved in the recognition of the RPP1 defense proteins of the different Arabidopsis thaliana ecotypes. {ECO:0000269\|PubMed:21788488, ECO:0000269\|PubMed:26725254}.
Miscellaneous:		The ATR1 effector protein of Hyaloperonospora arabidopsidis is a polymorphic member of the RXLR class of secreted effectors. The ATR1 alleles are differentially recognized by RPP1 genes from different Arabidopsis ecotypes (Niederzenz, Wassilewskija, Estland and Zdarec). {ECO:0000269\|PubMed:15894715, ECO:0000269\|PubMed:22194907, ECO:0000269\|PubMed:25671309, ECO:0000269\|PubMed:26725254}.
Similarity:		Belongs to the RxLR effector family. {ECO:0000305}.