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PDBsum entry 3rmb
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Transferase/DNA
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PDB id
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3rmb
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References listed in PDB file
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Key reference
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Title
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A crystallographic study of the role of sequence context in thymine glycol bypass by a replicative DNA polymerase serendipitously sheds light on the exonuclease complex.
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Authors
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P.Aller,
S.Duclos,
S.S.Wallace,
S.Doublié.
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Ref.
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J Mol Biol, 2011,
412,
22-34.
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PubMed id
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Abstract
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No abstract given.
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Secondary reference #1
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Title
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A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, Thymine glycol.
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Authors
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P.Aller,
M.A.Rould,
M.Hogg,
S.S.Wallace,
S.Doublié.
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Ref.
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Proc Natl Acad Sci U S A, 2007,
104,
814-818.
[DOI no: ]
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PubMed id
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Figure 1.
Fig. 1. Tg is the product of ionizing radiation and
oxidation.  -irradiation produces
equal amounts of the (5R, 6S) and (5S, 6R) cis isomers, whereas
oxidation generates preferentially the (5R, 6S) isomer.
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Figure 5.
Fig. 5. Interaction of Tg with surrounding bases.
Superposition of the Tg·acyAMP complex (green) with an
incipient base pair (A·dTTP) from an RB69 gp43 complex
with normal DNA (29) (yellow; PDB ID code 1IG9). The adenine
(yellow) overlaid on the Tg·acyAMP structure (green)
illustrates that the methyl group of Tg would sterically clash
with the six-member ring of any purine base in the insertion
site (i). The displaced 5'-guanine (green) rotates out of the
way and is stabilized by two hydrogen bonds with Tg. Tg also
interacts with the 3'-guanine via a water-mediated interaction.
Water molecules are shown as red spheres.
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