PDBsum entry 3rl7

Membrane protein/signaling protein

PDB id: 3rl7

Contents

Protein chains

89 a.a.

90 a.a.

82 a.a.

Ligands

SER-TYR-LEU-VAL-THR-SER-VAL

TYR-LEU-VAL-THR-SER ×2

TYR-LEU-VAL-THR-SER-VAL

LEU-VAL-THR-SER-VAL

LEU-VAL-THR-SER

Waters ×57

PDB id:

3rl7

Name:

Membrane protein/signaling protein

Title:

Crystal structure of hdlg1-pdz1 complexed with apc

Structure:

Disks large homolog 1. Chain: b, a, c, d, e, f. Fragment: unp residues 220-317. Synonym: synapse-associated protein 97, sap-97, sap97, hdlg. Engineered: yes. 11-mer peptide from adenomatous polyposis coli protein. Chain: g, h, i, j, k, l. Synonym: apc-c11. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dlg1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans

Resolution:

2.30Å R-factor: 0.194 R-free: 0.231

Authors:

Z.Zhang,H.Li,G.Wu

Key ref:

Z.Zhang et al. (2011). Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein. Plos One, 6, e23507. PubMed id: 21858148

Date:

19-Apr-11 Release date: 14-Dec-11

Protein chains

Q12959  (DLG1_HUMAN) -  Disks large homolog 1 from Homo sapiens

Seq: 904 a.a.

Struc: 89 a.a.*

Protein chains

Q12959  (DLG1_HUMAN) -  Disks large homolog 1 from Homo sapiens

Seq: 904 a.a.

Struc: 90 a.a.

Protein chain

Q12959  (DLG1_HUMAN) -  Disks large homolog 1 from Homo sapiens

Seq: 904 a.a.

Struc: 82 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains B, A, C, D, E, F: E.C.?

Plos One 6:e23507 (2011)

PubMed id: 21858148

Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein.

Z.Zhang, H.Li, L.Chen, X.Lu, J.Zhang, P.Xu, K.Lin, G.Wu.

ABSTRACT

No abstract given.