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PDBsum entry 3rei
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protein dna_rna ligands metals Protein-protein interface(s) links
Structural protein/DNA PDB id
3rei

 

 

 

 

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Contents
Protein chains
97 a.a.
82 a.a.
106 a.a.
95 a.a.
87 a.a.
DNA/RNA
Ligands
SO4 ×3
Metals
_PT ×49
_MN ×2
PDB id:
3rei
Name: Structural protein/DNA
Title: 2.65 angstrom crystal structure of the nucleosome core particle assembled with a 145 bp alpha-satellite DNA (ncp145) derivatized with triamminechloroplatinum(ii) chloride
Structure: Histone h3.2. Chain: a, e. Engineered: yes. Histone h4. Chain: b, f. Engineered: yes. Histone h2a type1. Chain: c, g. Engineered: yes.
Source: Xenopus laevis. Clawed frog,common platanna,platanna. Organism_taxid: 8355. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Homo sapiens. Organism_taxid: 9606. Organism_taxid: 9606
Resolution:
2.65Å     R-factor:   0.260     R-free:   0.276
Authors: B.Wu,C.A.Davey
Key ref: B.Wu et al. (2011). Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation. Nucleic Acids Res, 39, 8200-8212. PubMed id: 21724603
Date:
04-Apr-11     Release date:   14-Mar-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P84233  (H32_XENLA) -  Histone H3.2 from Xenopus laevis
Seq:
Struc: 		136 a.a.
97 a.a.*
Protein chain
Pfam   ArchSchema ?
P62799  (H4_XENLA) -  Histone H4 from Xenopus laevis
Seq:
Struc: 		103 a.a.
82 a.a.
Protein chains
Pfam   ArchSchema ?
P06897  (H2A1_XENLA) -  Histone H2A type 1 from Xenopus laevis
Seq:
Struc: 		130 a.a.
106 a.a.*
Protein chains
Pfam   ArchSchema ?
P02281  (H2B11_XENLA) -  Histone H2B 1.1 from Xenopus laevis
Seq:
Struc: 		126 a.a.
95 a.a.*
Protein chain
Pfam   ArchSchema ?
P62799  (H4_XENLA) -  Histone H4 from Xenopus laevis
Seq:
Struc: 		103 a.a.
87 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

DNA/RNA chains
  A-T-C-A-A-T-A-T-C-C-A-C-C-T-G-C-A-G-A-T-A-C-T-A-C-C-A-A-A-A-G-T-G-T-A-T-T-T-G- 145 bases
  A-T-C-A-A-T-A-T-C-C-A-C-C-T-G-C-A-G-A-T-A-C-T-A-C-C-A-A-A-A-G-T-G-T-A-T-T-T-G- 145 bases

 

 
Nucleic Acids Res 39:8200-8212 (2011)
PubMed id: 21724603  
 
 
Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation.
B.Wu, G.E.Davey, A.A.Nazarov, P.J.Dyson, C.A.Davey.
 
  ABSTRACT  
 
No abstract given.

 

 

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