UniProt functional annotation for Q9H3S7

UniProt code: Q9H3S7.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:21757351}.
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
Subunit: Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B. {ECO:0000269|PubMed:18434552, ECO:0000269|PubMed:21179510, ECO:0000269|PubMed:21757351}.
Subcellular location: Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. {ECO:0000305}.
Similarity: Contains 1 BRO1 domain. {ECO:0000255|PROSITE- ProRule:PRU00526}.
Similarity: Contains 2 TPR repeats. {ECO:0000305}.
Similarity: Contains 1 tyrosine-protein phosphatase domain. {ECO:0000255|PROSITE-ProRule:PRU00160}.
Sequence caution: Sequence=BAA95995.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.