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PDBsum entry 3raj
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Hydrolase/immune system
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PDB id
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3raj
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Contents |
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230 a.a.
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215 a.a.
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208 a.a.
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PDB id:
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| Name: |
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Hydrolase/immune system
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Title:
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Crystal structure of human cd38 in complex with the fab fragment of antibody hb7
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Structure:
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Adp-ribosyl cyclase 1. Chain: a. Fragment: extracellular domain, residues 46-300. Synonym: cyclic adp-ribose hydrolase 1, cadpr hydrolase 1, t10. Engineered: yes. Mutation: yes. Heavy chain of the fab fragment of antibody hb7. Chain: h. Engineered: yes.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cd38. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Mus musculus. Mouse. Organism_taxid: 10090.
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Resolution:
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3.04Å
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R-factor:
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0.208
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R-free:
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0.275
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Authors:
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H.Zhang,H.C.Lee,Q.Hao
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Key ref:
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H.Zhang
et al.
Engineering a novel cytosolic form of cd38 for cyclic ADP-Ribose dependent signaling.
To be published,
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Date:
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28-Mar-11
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Release date:
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27-Apr-11
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PROCHECK
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Headers
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References
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P28907
(CD38_HUMAN) -
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 from Homo sapiens
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Seq:
Struc:
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300 a.a.
230 a.a.*
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Enzyme class 2:
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Chain A:
E.C.2.4.99.20
- 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase.
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Reaction:
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nicotinate + NADP+ = nicotinate-adenine dinucleotide phosphate + nicotinamide
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nicotinate
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+
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NADP(+)
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=
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nicotinate-adenine dinucleotide phosphate
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+
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nicotinamide
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Enzyme class 3:
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Chain A:
E.C.3.2.2.-
- ?????
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Enzyme class 4:
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Chain A:
E.C.3.2.2.6
- ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
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Reaction:
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NAD+ + H2O = ADP-D-ribose + nicotinamide + H+
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NAD(+)
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+
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H2O
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=
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ADP-D-ribose
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+
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nicotinamide
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
