PDBsum entry 3r7x

Transport protein

PDB id

3r7x

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Contents

			Protein chains

					259 a.a.

			Ligands

					QSN


					GLU

			Waters ×446

PDB id:

3r7x

Links

Name:

Transport protein

Title:

Crystal structure analysis of a quinazolinedione sulfonamide bound to human glur2: a novel class of competitive ampa receptor antagonists with oral activity

Structure:

Glutamate receptor 2. Chain: a, b. Fragment: see remark 999. Synonym: glur-2, ampa-selective glutamate receptor 2, glur-b, glur- k2, glutamate receptor ionotropic, ampa 2, glua2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.10Å

R-factor:

0.206

R-free:

0.250

Authors:

J.Kallen

Key ref:

M.Koller et al. (2011). Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity. Bioorg Med Chem Lett, 21, 3358-3361. PubMed id: 21531559

Date:

23-Mar-11

Release date:

18-May-11

PROCHECK

	Headers

	References

Protein chains

P42262 (GRIA2_HUMAN) - Glutamate receptor 2 from Homo sapiens

Seq: Struc:

Seq: Struc:					883 a.a. 259 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

	Bioorg Med Chem Lett 21:3358-3361 (2011)
PubMed id: 21531559

Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.
M.Koller, K.Lingenhoehl, M.Schmutz, I.T.Vranesic, J.Kallen, Y.P.Auberson, D.A.Carcache, H.Mattes, S.Ofner, D.Orain, S.Urwyler.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22412620

F.Gao, Y.F.Hu, and J.L.Wang (2012).
2,4-Dichloro-7-fluoro-quinazoline.

Acta Crystallogr Sect E Struct Rep Online, 68, o740.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.