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PDBsum entry 3r7o
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Transferase/transferase inhibitor
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PDB id
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3r7o
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Structure of dually phosphorylated c-met receptor kinase in complex with an mk-2461 analog
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Structure:
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Hepatocyte growth factor receptor. Chain: a. Fragment: kinase domain (unp residues 1048-1348). Synonym: proto-oncogenE C-met, hgf receptor, hgf/sf receptor, scatter factor receptor, sf receptor, tyrosine-protein kinase met. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: met. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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2.30Å
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R-factor:
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0.213
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R-free:
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0.240
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Authors:
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S.M.Soisson,K.Rickert,S.B.Patel,S.Munshi,K.J.Lumb
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Key ref:
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K.W.Rickert
et al.
(2011).
Structural basis for selective small molecule kinase inhibition of activated c-Met.
J Biol Chem,
286,
11218-11225.
PubMed id:
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Date:
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22-Mar-11
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Release date:
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01-Feb-12
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PROCHECK
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Headers
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References
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P08581
(MET_HUMAN) -
Hepatocyte growth factor receptor from Homo sapiens
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Seq:
Struc:
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1390 a.a.
301 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.10.1
- receptor protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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J Biol Chem
286:11218-11225
(2011)
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PubMed id:
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Structural basis for selective small molecule kinase inhibition of activated c-Met.
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K.W.Rickert,
S.B.Patel,
T.J.Allison,
N.J.Byrne,
P.L.Darke,
R.E.Ford,
D.J.Guerin,
D.L.Hall,
M.Kornienko,
J.Lu,
S.K.Munshi,
J.C.Reid,
J.M.Shipman,
E.F.Stanton,
K.J.Wilson,
J.R.Young,
S.M.Soisson,
K.J.Lumb.
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ABSTRACT
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Links
