PDBsum entry 3r63

Transferase

PDB id: 3r63

Contents

Protein chain

347 a.a.

Waters ×161

PDB id:

3r63

Name:

Transferase

Title:

Structure of erk2 (spe) mutant (s246e)

Structure:

Mitogen-activated protein kinase 1. Chain: a. Synonym: map kinase 1, mapk 1, ert1, extracellular signal-regulated kinase 2, erk-2, map kinase isoform p42, p42-mapk, mitogen-activated protein kinase 2, map kinase 2, mapk 2. Engineered: yes. Mutation: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: mapk1, erk2, mapk, prkm1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.70Å R-factor: 0.191 R-free: 0.245

Authors:

O.Livnah,Y.Karamansha

Key ref:

A.Plotnikov et al. (2011). Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation. Mol Cell Biol, 31, 3515-3530. PubMed id: 21730285

Date:

21-Mar-11 Release date: 17-Aug-11

Protein chain

P63086  (MK01_RAT) -  Mitogen-activated protein kinase 1 from Rattus norvegicus

Seq: 358 a.a.

Struc: 347 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Mol Cell Biol 31:3515-3530 (2011)

PubMed id: 21730285

Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation.

A.Plotnikov, D.Chuderland, Y.Karamansha, O.Livnah, R.Seger.

ABSTRACT

No abstract given.